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Recent Publications

2020

  • Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C (2020) Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 2020 Jan 21;9(2):260. doi: 3390/cells9020260. PMID: 31972963
  • Barboni MTS, Vaillend C, Joachimsthaler A, Liber AMP, Khabou H, Roux MJ, Vacca O, Vignaud L, Dalkara D, Guillonneau X, Ventura DF, Rendon A, Kremers J (2020) Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71. Invest Ophtalmol Vis Sci. 2020 Feb 7;61(2):11. doi: 1167/iovs.61.2.11. PMID: 32049345
  • von Wittgenstein J*, Zheng F, Wittmann MT, Balta EA, Ferrazzi F, Schäffner I, Häberle BM, Valero-Aracama MJ, Koehl M, Miranda CJ, Kaspar BK, Ekici AB, Reis A, Abrous DN, Alzheimer C, Lie DC*. (2020) Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex. 2020 May 18;30(6):3731-3743. doi: 1093/cercor/bhz338. PMID: 32080705
  • Feigenspan A, Ohs A, von Wittgenstein J, Brandstätter JH, Babai N (2020) Analysis of tetrodotoxin-sensitive sodium and low voltage-activated calcium channels in developing mouse retinal horizontal cells. Exp Eye Res. 2020 Jun;195:108028. doi: 1016/j.exer.2020.108028. Epub 2020 Apr 8. PMID: 32277973
  • Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M (2020) Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development. J Neurosci. 2020 Jun 17;40(25):4824-4841. doi: 1523/JNEUROSCI.1707-19.2020. Epub 2020 May 15. PMID: 32414783
  • Montenegro-Venegas C, Fienko S, Anni D, Pina-Fernández E, Frischknecht R, Fejtova A (2020) Bassoon inhibits proteasome activity via interaction with PSMB4. Cell Mol Life Sci. 2020 Jul 10. doi: 1007/s00018-020-03590-z. Online ahead of print. PMID: 32651614

2019

  • Müller TM, Gierke K, Joachimsthaler A, Sticht H, Izsvák Z, Hamra FK, Fejtová A, Ackermann F, Garner CC, Kremers J, Brandstätter JH*, Regus-Leidig H* (2019) A multiple Piccolino-RIBEYE interaction supports plate-shaped synaptic ribbons in retinal neurons. J Neurosci 39:2606-2619. doi: 10.1523/JNEUROSCI.2038-18.2019 (*shared corresponding authors).
  • Joachimsthaler A & Kremers J (2019) Mouse Cones Adapt Fast, Rods Slowly In Vivo. Invest Ophthalmol Vis Sci 60(6): 2152-2564. doi: 10.1167/iovs.18-26356.
  • Taylor RW, Mahmoodabadi RG, Rauschenberger V, Giessl A, Schambony A, Sandoghdar V (2019) Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane. Nature Photonics. doi.org/10.1038/s41566-019-0414-6.
  • Hartmut Niekisch, Julia Steinhardt, Julia Berghäuser, Sara Bertazzoni, Erika Kaschinski, Jana Kasper, Martin Kisse, Jessica Mitlöhner, Jeet B. Singh, Judith Weber, Renato Frischknecht,*, Max F. K. Happel* (2019) Learning induces transient upregulation of brevican in auditory cortex during consolidation of long-term memories. J Neurosci Sep 4;39(36):7049-7060. doi: 10.1523/JNEUROSCI.2499-18.2019. Epub 2019 Jun 19. (*shared corresponding authors).
  • Falk N, Joachimsthaler A, Kessler K, Lux UT, Noegel AA, Kremers J, Brandstätter JH, Gießl A (2019) Lack of a retinal phenotype in a Syne-2/Nesprin-2 knockout mouse model. Cells 11;8(10). pii: E1238. doi: 10.3390/cells8101238.
  • Klotz L, Wendler O, Frischknecht R, Shigemoto R, Schulze H, Enz R (2019) Localization of group II and III metabotropic glutamate receptors at pre- and postsynaptic sites of inner hair cell ribbon synapses. FASEB J Oct 4:fj201901543R. doi: 10.1096/fj.201901543R [Epub ahead of print].
  • Barro-Soria R, Caicedo A, Jägle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauß O (2019) Angiotensin-receptor associated protein modulates synaptic Ca2+ signals in photoreceptor and mossy fiber cells. Scientific Reports. Doi.org/10.1038/s41598-019-55380-8.
  • Hermann M, Reumann R, Schostak K, Kement D, Gelderblom M, Bernreuther C, Frischknecht R, Schipanski A, Marik S, Krasemann S, Sepulveda-Falla D, Schweizer M, Magnus T, Glatzel M, Galliciotti G (2019) Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin. Mol Cell Neurosci. doi: 10.1016/j.mcn.2019.103420. [Epub ahead of print]

2018

  • Trollmann R, Mühlberger T, Richter M, Boie G, Feigenspan A, Brackmann F, Jung S (2018) Differential regulation of angiogenesis in the developing mouse brain in response to exogenous activation of the hypoxia-inducible transcription factor system. Brain Res. doi: 10.1016/j.brainres.2018.03.012. Epub 2018 Mar 13.
  • Babai N, Gierke K, Regus-Leidig H, Müller T, Brandstätter JH, Feigenspan A (2018) Signal transmission at invaginating cone photoreceptor synaptic contacts following deletion of the presynaptic cytomatrix protein Bassoon in mouse retina. Acta Physiol. doi: 10.1111/apha.13241.
  • Pandya, N.J., Seeger, C., Babai, N., Gonzalez-Lozano, M.A., Mack, V., Lodder, J.C., Gouwenberg, Y., Mansvelder, H.D., Danielson, U.H., Li, K.W., Heine, M., Spijker, S., Frischknecht, R. & Smit, A.B. (2018) Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors. Cell Rep, 24, 1218-1230.
  • Falk N, Kessler K, Schramm SF, Bold K, Becirovic E, Michalakis S, Regus-Leidig H, Noegel AA, Ueffing M, Thiel CT, Roepman R, Brandstätter JH, Gießl A (2018) Functional analyses of Pericentrin and Syne-2/Nesprin-2 interaction in ciliogenesis. J Cell Sci. doi: 10.1242/jcs.218487.
  • Eulenburg V, Knop G, Sedmak T, Schuster S, Hauf K, Schneider J, Feigenspan A, Joachimsthaler A, Brandstätter JH (2018) GlyT1 determines the glycinergic phenotype of amacrine cells in the mouse retina. Brain Struct Funct. doi.org/10.1007/s00429-018-1684-3.

2017

  • Tsai TI, Joachimsthaler A, Kremers J (2017) Mesopic and photopic rod and cone photoreceptor-driven visual processes in mice with long-wavelength-shifted cone pigments. Invest Opththal Vis Sci 58:5177-5187. doi: 10.1167/iovs.17-22553.
  • Feigenspan A, Babai N (2017) Preparation of horizontal slices of adult mouse retina for electrophysiological studies. J Vis Exp. doi: 10.3791/55173.
  • Kurtenbach S, Gießl A, Strömberg S, Kremers J, Atorf J, Rasche S, Neuhaus EM, Hervé D, Brandstätter JH, Asan E, Hatt H, Kilimann MW (2017) The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia. Sci Rep 7(1):8409. doi: 10.1038/s41598-017-08543-4.
  • Van Hook MJ, Babai N, Zurawski Z, Yim YY, Hamm HE, Thoreson WB (2017) A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina. J Neurosci 37(17):4618-4634. doi: 10.1523/JNEUROSCI.2948-16.2017.
  • Schweitzer, B., Singh, J., Fejtova, A., Groc, L., Heine, M. & Frischknecht, R. (2017) Hyaluronic acid based extracellular matrix regulates surface expression of GluN2B containing NMDA receptors. Sci Rep, 7, 10991.
  • Löhner M, Babai N, Müller T, Gierke K, Altorf J, Joachimsthaler A, Peukert A, Martens H, Feigenspan A, Kremers J, Schoch S, Brandstätter JH, Regus-Leidig H (2017) Analysis of RIM expression and function at mouse photoreceptor ribbbon synapses. J Neurosci 37(33):7848-63. doi: 10.1523/JNEUROSCI.2795-16.2017.
  • Böhm S, Riedmayr LM, Phuong Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E (2017) Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants. Sci Rep 7(1):2321. doi: 10.1038/s41598-017-02514-5.

2016

  • Kochubey O, Babai N, Schneggenburger R (2016) A Synaptotagmin Isoform Switch during the Development of an Identified CNS Synapse. Neuron 90(5):984-99. doi: 10.1016/j.neuron.2016.04.038.
  • Babai N, Sendelbeck A, Regus-Leidig H, Fuchs M, Mertins J, Reim K, Brose N, Feigenspan A, Brandstätter JH (2016) Functional roles of Complexin3 and Complexin4 at mouse photoreceptor ribbon synapses. J Neurosci 36(25):6651-67. doi: 10.1523/JNEUROSCI.4335-15.2016.
  • Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2016) Studying protein function and the role of altered protein expression by antibody interference and three-dimensional reconstructions. J Vis Exp 110, e53049, doi:10.3791/53049. [Article and Video].
  • Nguyen ON, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandstätter JH, Wahl-Schott C, Biel M, Becirovic E (2016) Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum Mol Genet 25(12):2367-2377. doi: 10.1093/hmg/ddw103.

2015

  • Gotthardt K, Lokaj M, Koerner C, Falk N, Gießl A, Wittinghofer A (2015) A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins. eLife 4. pii: e11859. doi: 10.7554/eLife.11859. [Article].
  • Falk N, Lösl M, Schröder N, Gießl A (2015) Specialized Cilia in Mammalian Sensory Systems. Cells 4(3), 500-519; Review; doi:10.3390/cells4030500. [Article] [Special Issue Cilia and Flagella]
  • Zebrowski DC, Vergarajauregui S, Wu CC, Piatkowski T, Becker R, Leone M, Hirth S, Ricciardi F, Falk N, Gießl A, Just S, Braun T, Weidinger G, Engel FB (2015) Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. eLife 4. doi: 10.7554/eLife.05563. [Article]. Article in FAU News.
  • Feigenspan A, Babai N (2015) Functional properties of spontaneous excitatory currents and encoding of light/dark transitions in horizontal cells of the mouse retina. Eur J Neurosci 42(9):2615-32. doi: 10.1111/ejn.13016.
  • Wheway G, Schmidts M, Mans DA,…, Kessler K, Gießl A,…,Thiel CT, et al. (2015) An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol 17(8):1074-87. doi: 10.1038/ncb3201
  • Kessler K, Wunderlich I, Uebe S, Falk NS, Gießl A, Brandstätter JH, Popp B, Klinger P, Ekici AB, Sticht H, Dörr HG, Reis A, Roepman R, Seemanová E, Thiel CT (2015) DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects. Sci Rep 5:11649. doi: 10.1038/srep11649.
  • Derlig K, Gießl A, Brandstätter JH, Enz R, Dahlhaus R (2015) Special characteristics of the transcription and splicing machinery in photoreceptor cells of the mammalian retina. Cell Tissue Res 362(2):281-94. doi: 10.1007/s00441-015-2204-x.
  • Zahnleiter D, Hauer NN, Kessler K, Uebe S, Sugano Y, Neuhauss SC, Gießl A, Ekici AB, Blessing H, Sticht H, Dörr HG, Reis A, Thiel CT (2015) MAP4-dependent regulation of microtubule formation affects centrosome, cilia, and golgi architecture as a central mechanism in growth regulation. Hum Mutat 36(1):87-97. doi: 10.1002/humu.22711.